Réaction #84047

Équation de réaction

barbituric acid

3,5-dibromo-2-hydroxybenzaldehyde

→

product 1a

Rendement 84.6%

5-(3,5-dibromo-2-hydroxybenzylidene) perhydropyrimidine-2,4,6-trione

Rendement 84.6%

Solvants

acetic acid

Conditions de réaction

Traitement

1. 1
   Températurewhile heating
2. 2
   Autrethe resulting reaction mixture
3. 3
   FiltrationThe produced crystal product was filtered
4. 4
   Lavagewashed with cold acetic acid
5. 5
   Lavagewashed with ether
6. 6
   Autreair-dried

Mode opératoire

0.01 mol (1.28 g) of barbituric acid (5a) were dissolved in 25 ml of glacial acetic acid while heating. Then 0.011 mol (3.08 g) of 3,5-dibromo-2-hydroxybenzaldehyde (6a) were added to the obtained solution while stirring and the resulting reaction mixture was left at room temperature during 36 hours. The produced crystal product was filtered, washed with cold acetic acid, then washed with ether and air-dried. Thereby 3.3 g of product 1a were obtained in the form of yellow needle crystals with melting temperature of 255-260° C. (with decomposition). Output amounted to 77% of the theoretical value.

Source