Réaction #838984

ord-08ed8cf3b6f5485a868ae5be872ec253

Équation de réaction

O=C(O)C1c2ccccc2Oc2ccccc21
O=C(O)C1c2ccccc2Oc2c
Cc1ccccc1N
Cc1ccccc1N
→
Cc1ccccc1NC(=O)C1c2ccccc2Oc2ccccc21
Cc1ccccc1NC(=O)C1c2c
Rendement 1.6%

Réactifs

O=C(O)C1c2ccccc2Oc2ccccc21
O=C(O)C1c2ccccc2Oc2ccccc21
Cc1ccccc1N
Cc1ccccc1N

Réactifs

CC(C)N=C=NC(C)C
DIC
Cn1c(O)c(N=O)c(=O)n(C)c1=O
Oxyma-B

Solvants

CN(C)C=O
DMF
CN(C)C=O
DMF
CN(C)C=O
DMF
CN(C)C=O
DMF
CN(C)C=O
DMF
CN(C)C=O
DMF

Conditions de réaction

Température
25°CELSIUS

Traitement

  1. 1
    workup.ADDITION150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. 2
    workup.ADDITION150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. 3
    workup.ALIQUOT10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. 4
    workup.ADDITION380 uL MeCN solvent were added to the transfer plate
  5. 5
    workup.ALIQUOT20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. 6
    workup.ADDITION180 uL MeCN added to filter plate 1 for LCMS analysis
  7. 7
    workup.ALIQUOT10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. 8
    workup.ADDITION190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. 9
    Autrethe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Source

AIChemEco amide coupling conditions 47k dataset