Réaction #83846

Équation de réaction

2-bromobenzoic acid hydrazide

benzensulfonyl chloride

→

2-bromobenzoic acid 2-phenylsulfonylhydrazide

Solvants

pyridine

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONAfter complete addition
2. 2
   Autreto precipitate a yellow solid, 135 g
3. 3
   AutreThe material was recrystallized from isopropanol

Mode opératoire

To a solution of 2-bromobenzoic acid hydrazide (132 g) in pyridine (1.2 L) cooled to about 10 C with an ice bath, was added benzensulfonyl chloride (78.3 ml). After complete addition, the reaction was stirred at ambient temperature for four hours, and then poured into ice-hydrochloric acid to precipitate a yellow solid, 135 g. The material was recrystallized from isopropanol to yield 125 g of 2-bromobenzoic acid 2-phenylsulfonylhydrazide, m.p.=154°-156° C.

Source