Réaction #83835

Équation de réaction

phosphate

2-Methyl-4,5-dihydrofuran

mercaptoacetic acid

p-toluenesulfonic acid mono-hydrate

→

26

2-Carboxymethylthio-2-methyltetrahydrofuran

Solvants

water

ethyl acetate

dichloromethane

dichloromethane

Conditions de réaction

Traitement

1. 1
   Températureis cooled
2. 2
   Températureis maintained between -10° C. to -25° C
3. 3
   Autreto come to room temperature
4. 4
   AutreOrganic layer is separated
5. 5
   Extractionthe aqueous layer is extracted with ethyl acetate
6. 6
   SéchageThe combined ethyl acetate layer is dried
7. 7
   Autreevaporated

Mode opératoire

A solution of mercaptoacetic acid (10 mmol) in 5 mL of dichloromethane containing p-toluenesulfonic acid mono-hydrate (100 mg) is cooled with stirring to -10° to -25° C. 2-Methyl-4,5-dihydrofuran (10 mmol) in 10 mL of dichloromethane is added dropwise to the cold solution while the temperature is maintained between -10° C. to -25° C. Then 5 mL of phosphate buffer is added and the solution is allowed to come to room temperature. The mixture is poured into a 30 mL of ethyl acetate and 10 mL of water. Organic layer is separated and the aqueous layer is extracted with ethyl acetate. The combined ethyl acetate layer is dried and evaporated to give 26 as a colorless oil.

Source