Réaction #836426

Équation de réaction

4-(Benzyloxy)-7-((1R)-2-{benzyl[6-(4-phenylbutoxy)hexyl]amino}-1-hydroxyethyl)-1,3-benzothiazol-2(3H)-one

formic acid

→

title compound

4-Hydroxy-7-((1R)-1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)-1,3-benzothiazol-2(3H)-one formate

Conditions de réaction

Traitement

1. 1
   Autrethe catalyst was removed by filtration through celite
2. 2
   Autrethe filtrate evaporated in vacuo
3. 3
   AutreThe residue was purified on mass

Mode opératoire

4-(Benzyloxy)-7-((1R)-2-{benzyl[6-(4-phenylbutoxy)hexyl]amino}-1-hydroxyethyl)-1,3-benzothiazol-2(3H)-one (7.4 mg) was dissolved in 98% formic acid (0.5 ml)and palladium black catalyst (4 mg) added. After stirring for 8 h, the catalyst was removed by filtration through celite and the filtrate evaporated in vacuo. The residue was purified on mass directed autoprep, to give the title compound (0.51 mg). LCMS RT=2.95 min. ES+ve 459 (M+H)+

Source