Réaction #831164

Équation de réaction

2-Chloro-3-nitrothiophene

Sodium hydroxide

4,6-dimethoxy-2-mercaptopyrimidine

→

desired product

Rendement 83.1%

4,6-Dimethoxy-2-(3-nitro-2-thienylthio)pyrimidine

Rendement 83.1%

Solvants

ethanol

water

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONwas added
2. 2
   workup.STIRRINGwith stirring
3. 3
   workup.STIRRINGthe mixture being stirred at room temperature for 6 hours
4. 4
   FiltrationThe resulting precipitate was filtered
5. 5
   Lavagewashed with water
6. 6
   Autredried

Mode opératoire

Sodium hydroxide (1.2 g) was dissolved in water (50 ml), 4,6-dimethoxy-2-mercaptopyrimidine (5.3 g) was added, and the mixture was stirred at room temperature for 15 minutes. 2-Chloro-3-nitrothiophene (5.0 g) dissolved in ethanol (50 ml) was added with stirring, the mixture being stirred at room temperature for 6 hours. The resulting precipitate was filtered, washed with water and dried, to give 7.6 g of the desired product, mp 199°-201° C.

Source