Réaction #82954

Équation de réaction

2-benzyl-4-(3,4-dihydroxyphenyl)-8-formamido-7-hydroxy-1,2,3,4-tetrahydroisoquinoline

hydrochloric acid

→

4-(3,4-dihydroxyphenyl)-8-formamido-7-hydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

Rendement 82.4%

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONafter adding
2. 2
   Autrewas performed at room temperature
3. 3
   AutreThe hydrogenation reaction
4. 4
   Filtrationwas filtered
5. 5
   Concentrationconcentrated
6. 6
   Autreto precipitates with treatment of isopropyl alcohol and acetonitrile
7. 7
   Filtrationthe precipitates was collected by filtration

Mode opératoire

450 mg of 2-benzyl-4-(3,4-dihydroxyphenyl)-8-formamido-7-hydroxy-1,2,3,4-tetrahydroisoquinoline was dissolved in 9 ml of ethanol, and after adding thereto 0.86 ml of 2M hydrochloric acid 0.05 g of 10% paradium-carbon, hydrogenation reaction was performed at room temperature. The hydrogenation reaction was over, the reaction mixture was filtered, and concentrated. The residue was changed to precipitates with treatment of isopropyl alcohol and acetonitrile, and the precipitates was collected by filtration, affording 320 mg of 4-(3,4-dihydroxyphenyl)-8-formamido-7-hydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride.

Source