Réaction #82767

Équation de réaction

5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

4-(3-pyrrolidinyl)pyridine

→

title compound

Rendement 48.0%

5-Amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo -7-[3-(4-pyridinyl)-1-pyrrolidinyl]-3-quinoline-carboxylic acid

Rendement 48.0%

Conditions de réaction

Mode opératoire

Starting from 5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (1.10 g, 3.7 mmol) and 4-(3-pyrrolidinyl)pyridine, a procedure analogous to that given in Example 1 provided the title compound (0.75 g, 48%) as a yellow solid, mp 236°-238° C.

Source