Réaction #82110

Équation de réaction

sulfuric acid

3-ethoxy-4-hydroxybenzaldehyde

aniline

Malonic acid

→

compound

Rendement 56.1%

3-ethoxy-4-hydroxycinnamic acid

Rendement 56.1%

Solvants

pyridine

Conditions de réaction

Traitement

1. 1
   AutreThe crude crystals were obtained by filtration
2. 2
   Lavagewashed with water
3. 3
   Autredried

Mode opératoire

Malonic acid (1.56 g) and pyridine (3.0 ml) were placed in an egg-plant type flask (100 ml). Further, 3-ethoxy-4-hydroxybenzaldehyde (1.66 g) and aniline (30 μl) were added thereto and a reaction was performed at 55° C. for 3 hours. The reaction solution was acidified by adding dilute sulfuric acid. The crude crystals were obtained by filtration, washed with water, and then dried to obtain the above-identified compound (1.1 g, 56.1%) as a light yellowish crystal. Melting point: 157°-158° C.

Source