Réaction #81685

Équation de réaction

n-propyl isocyanate

2-iodo benzene sulfonamide

K2CO3

acetone isopropyl ether

→

title compound

2-iodobenzene n-propylsulfonylurea

Solvants

acetone

Conditions de réaction

Traitement

1. 1
   Températurethe mixture is refluxed under N2 -atmosphere
2. 2
   TempératureAfter 2 hours reflux
3. 3
   Concentrationconcentrated to dryness
4. 4
   workup.ADDITIONWater (200 ml) is added
5. 5
   Filtrationfiltered
6. 6
   AutreThe precipitate obtained

Mode opératoire

To a stirred solution of 2-iodo benzene sulfonamide (4 g) in acetone (40 mi) solid K2CO3 (3.92 g) is added in one portion and the mixture is refluxed under N2 -atmosphere, n-propyl isocyanate is added dropwise to the heated mixture. After 2 hours reflux, the reaction is cooled to room temperature and concentrated to dryness. Water (200 ml) is added and the cooled mixture is acidified with 2N HCl to pH 4 and filtered. The precipitate obtained is recristallised with acetone/isopropyl ether mixture to give 4.1 g solid of the title compound.

Source