Réaction #81643

Équation de réaction

carbon monoxide

methyl 3-carbamoylisobutyrate

methyl formate

carbon monoxide

→

dimethyl methylsuccinate

formamide

Solvants

methanol

methanol

Conditions de réaction

Traitement

1. 1
   Températurewith heating
2. 2
   Températureto maintain the internal pressure at 40 kg/cm2G
3. 3
   Autrereached 60° C.
4. 4
   Températureto maintain the internal pressure at 40 kg/cm2G
5. 5
   Autreto proceed with the reaction for 3 hours
6. 6
   TempératureSubsequently, the content therein was cooled
7. 7
   AutreAs a result of analysis

Mode opératoire

The procedure in Example 3 (3) was repeated to proceed with heating stirring reaction except that in place of 180 g of methyl formate and 96 g of methanol, 200 g of methanol was charged in the autoclave and carbon monoxide was pressurized into the autoclave so as to maintain the internal pressure at 40 kg/cm2G. After the temperature of the content in the autoclave reached 60° C., carbon monoxide was fed in the autoclave so as to maintain the internal pressure at 40 kg/cm2G to proceed with the reaction for 3 hours. Subsequently, the content therein was cooled, internal pressure was gradually lowered to atmospheric pressure, and the reaction product was taken out. As a result of analysis therefor, the conversion of methyl 3-carbamoylisobutyrate was 81.4% and there were obtained dimethyl methylsuccinate at a selectivity of 95.7% and formamide at a selectivity of 94.4%, each based on the reacted methyl 3-carbamoylisobutyrate.

Source