Réaction #816394

Équation de réaction

phytantriol

acetone

→

2-(2,2-dimethyl-[1,3]dioxolan-4-yl)-6,10,14-trimethyl-pentadecan-2-ol

Conditions de réaction

Traitement

1. 1
   Autrefor 15 hr
2. 2
   AutreAfter the completion of the reaction
3. 3
   Autrethe acetone solvent was removed under reduced pressure
4. 4
   Extractionthe resultant was extracted with chloroform solution
5. 5
   LavageThe extract was washed with saturated sodium bicarbonate solution
6. 6
   Lavagewas again washed with saline

Mode opératoire

One g of phytantriol (3.0 mmol, Sigma-Aldrich) was refluxed using deanstock apparatus for 15 hr in 25 ml of acetone solution with toluene sulfonic acid as catalyst. After the completion of the reaction, the acetone solvent was removed under reduced pressure and the resultant was extracted with chloroform solution. The extract was washed with saturated sodium bicarbonate solution and was again washed with saline to obtain 0.3 g of (2-(2,2-dimethyl-[1,3]dioxolan-4-yl)-6,10,14-trimethyl-pentadecan-2-ol) of which 1- and 2-positions were protected.

Source