Réaction #8149

Équation de réaction

2-fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene

ethylamine

→

2-(ethylamino)-4-(3-diethylamino-1-propoxy)nitrobenzene

Rendement 88.0%

Solvants

THF

Conditions de réaction

Traitement

1. 1
   AutreAfter completion of the reaction
2. 2
   Concentrationthe reaction mixture is concentrated in vacuo
3. 3
   workup.DISSOLUTIONThe residue is redissolved in EtOAc (10 mL)
4. 4
   Lavagewashed with saturated sodium bicarbonate solution, water, and brine
5. 5
   SéchageThe organic phase is then dried over sodium sulfate
6. 6
   Autrethe solvent is removed in vacuo

Mode opératoire

A solution of 2-fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene (2 mmol; preparation described in Example 5) in THF (5 mL) is treated with ethylamine (4 mmol) at rt. After completion of the reaction, the reaction mixture is concentrated in vacuo. The residue is redissolved in EtOAc (10 mL), washed with saturated sodium bicarbonate solution, water, and brine. The organic phase is then dried over sodium sulfate and the solvent is removed in vacuo to afford the product, 2-(ethylamino)-4-(3-diethylamino-1-propoxy)nitrobenzene (520 mg) which was used for further transformation without further purification.

Source