Réaction #812950

ord-f9129d94c8de4fec87c94f6e789d1b06

Équation de réaction

CC(=O)c1c(C)c2c(OS(=O)(=O)O)c(Cl)cc(C(F)(F)F)c2[nH]c1=O
3-Acetyl-6-chloro-4-methylsulfoxy-8-trifluoromethyl-2-quinolinone
CSCCN
methylthioethylamine
→
CSCCNc1c(C(C)=O)c(=O)[nH]c2c(C(F)(F)F)cc(Cl)cc12
desired product
Rendement 76.0%
CSCCNc1c(C(C)=O)c(=O)[nH]c2c(C(F)(F)F)cc(Cl)cc12
3-Acetyl-6-chloro-4-methylthioethylamino-8-trifluoromethyl-2-quinolinone
Rendement 76.0%

Réactifs

CC(=O)c1c(C)c2c(OS(=O)(=O)O)c(Cl)cc(C(F)(F)F)c2[nH]c1=O
3-Acetyl-6-chloro-4-methylsulfoxy-8-trifluoromethyl-2-quinolinone
CSCCN
methylthioethylamine

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

3-Acetyl-6-chloro-4-methylsulfoxy-8-trifluoromethyl-2-quinolinone (351 mg, 1 mmol) and methylthioethylamine (91 mg, 1 mmol) were used and the reaction was carried out as in the above process of example 1 to obtain the desired product (287 mg, yield: 76%).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US05707931uspto-grants-1998_01