Réaction #80903

Équation de réaction

2,4-diamino-5-chloro-6-(5-chloro-2-hydroxyphenyl)quinazoline

pyridin-2-ylmethyl chloride hydrochloride

potassium carbonate

→

2,4-diamino-5-chloro-6-[5-chloro-2-(pyridin-2-ylmethoxy)phenyl]quinazoline

Rendement 72.8%

Solvants

N,N-dimethylformamide

Conditions de réaction

Traitement

1. 1
   ConcentrationAfter this time, the reaction mixture was concentrated under reduced pressure to a residue
2. 2
   FiltrationThe resultant solid was collected by filtration

Mode opératoire

Under a nitrogen atmosphere, a stirred solution of 0.5 gram (0.002 mole) of 2,4-diamino-5-chloro-6-(5-chloro-2-hydroxyphenyl)quinazoline, 0.3 gram (0.002 mole) of pyridin-2-ylmethyl chloride hydrochloride, and 0.5 gram (0.004 mole) of potassium carbonate in 5 mL of N,N-dimethylformamide was heated at 60° C. for about 24 hours. After this time, the reaction mixture was concentrated under reduced pressure to a residue. The residue was taken up in 100 mL of water and was stirred for about 2 hours. The resultant solid was collected by filtration, yielding 0.6 gram of 2,4-diamino-5-chloro-6-[5-chloro-2-(pyridin-2-ylmethoxy)phenyl]quinazoline. The NMR spectrum was consistent with the proposed structure.

Source