Réaction #80709

Équation de réaction

ethyl acetate

N-(4-chloro-2-fluoro-5-nitrophenyl)-1-cyclohexene-1,2-dicarboximide

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title product

N-(5-Amino-4-chloro-2-fluorophenyl)-1-cyclohexene-1,2-dicarboximide

Solvants

acetic acid

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONAfter the addition
2. 2
   Filtrationfiltered through diatomaceous earth
3. 3
   ConcentrationThe filtrate is concentrated in vacuo
4. 4
   Autreto obtain a dark solid
5. 5
   Filtrationis filtered through diatomaceous earth
6. 6
   Autrethe phases are separated
7. 7
   LavageThe organic phase is washed sequentially with saturated sodium hydrogen carbonate solution and brine
8. 8
   Séchagedried over anhydrous magnesium sulfate
9. 9
   Concentrationconcentrated in vacuo

Mode opératoire

Iron powder (7.30 g, 130.7 mmol) is added portionwise to a mixture of N-(4-chloro-2-fluoro-5-nitrophenyl)-1-cyclohexene-1,2-dicarboximide (10.6 g, 32.7 mmol) in acetic acid (100 mL) at 65° C. After the addition is complete, the reaction mixture is stirred for 10 minutes, and filtered through diatomaceous earth. The filtrate is concentrated in vacuo to obtain a dark solid. A mixture of the solid in an ethyl acetate/saturated sodium hydrogen carbonate solution is filtered through diatomaceous earth, and the phases are separated. The organic phase is washed sequentially with saturated sodium hydrogen carbonate solution and brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to give the title product as a yellow solid.

Source