Réaction #80322

ord-1d6caa26a41b4f4d860feae9ccdb89b0

Équation de réaction

COc1cc2ncnc(Cl)c2cc1OC
4-chloro-6,7-dimethoxyquinazoline
Nc1cccc(O)c1
3-aminophenol
COc1cc2ncnc(Nc3cccc(O)c3)c2cc1OC
4-(3'-hydroxyanilino)-6,7-dimethoxyquinazoline
Rendement 92.0%

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

Using an analogous procedure to that described in Example 68, 4-chloro-6,7-dimethoxyquinazoline was reacted with 3-aminophenol to give 4-(3'-hydroxyanilino)-6,7-dimethoxyquinazoline in 92% yield, m.p. 256°-257° C.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US05616582uspto-grants-1997_04