Réaction #80261

Équation de réaction

Methyl 3-bromoadamantaneacetate

Aluminum trichloride

→

methyl 3-phenyl-1-adamantaneacetate

Solvants

benzene

Conditions de réaction

Traitement

1. 1
   AutreThe reaction mixture was then quenched by the addition of 0.5M phosphoric acid (1.6 L)
2. 2
   AutreThe layers were separated
3. 3
   Séchagethe organic layer was dried over sodium sulfate
4. 4
   Filtrationfiltered
5. 5
   Autreevaporated in vacuo

Mode opératoire

Methyl 3-bromoadamantaneacetate (80 g) (Aldrich Chemical Co. Milwaukee Wis.) was dissolved in benzene (1.6 L) under nitrogen. Aluminum trichloride (37.12 g) was added portionwise over 75 min. at ambient temperature. The reaction mixture was then quenched by the addition of 0.5M phosphoric acid (1.6 L). The layers were separated and the organic layer was dried over sodium sulfate, filtered, and evaporated in vacuo to give methyl 3-phenyl-1-adamantaneacetate (80 g).

Source