Réaction #79627

Équation de réaction

methyl 2-bromo-3-nitrobenzoate

sodium hydroxide

→

methyl 2-bromo-3-aminobenzoate

Rendement 99.2%

Solvants

hydrochloric acid

ethanol

Conditions de réaction

Traitement

1. 1
   TempératureThe mixture was cooled to room temperature
2. 2
   ExtractionThe resultant mixture was extracted three times with chloroform
3. 3
   LavageThe extracts were washed with brine
4. 4
   Séchagedried over sodium sulfate
5. 5
   Filtrationfiltered
6. 6
   Concentrationconcentrated

Mode opératoire

A solution of stannous chloride (15.0 g, 76.1 mM) in 30 mL of concentrated hydrochloric acid was slowly added to a solution of methyl 2-bromo-3-nitrobenzoate (4.0 g, 15.4 mM) in 90 mL ethanol at 15-30° C. over 1 hour. The mixture was then heated at 50-60° C. for 15 minutes. The mixture was cooled to room temperature and made alkaline by slow addition of solid sodium hydroxide maintaining a temperature of 30-35° C. The resultant mixture was extracted three times with chloroform. The extracts were washed with brine, dried over sodium sulfate, filtered and concentrated to afford 3.51 g (99%) of methyl 2-bromo-3-aminobenzoate as a yellow oil, identical in all respects to the material derived via catalytic hydrogenation described above.

Source