Réaction #792153

Équation de réaction

2-chloro-3-trifluoromethylpyridine

3-trifluoromethylpyrazole

potassium carbonate

→

title compound

Rendement 62.2%

3-Trifluoromethyl-2-[3-(trifluoromethyl)-1H-pyrazol-1-yl]pyridine

Rendement 62.2%

Solvants

Conditions de réaction

Traitement

1. 1
   AutreThe cooled reaction mixture
2. 2
   ExtractionThe mixture was extracted twice with ether (100 mL)
3. 3
   Lavagethe combined ether extracts were washed twice with water (100 mL)
4. 4
   SéchageThe organic layer was dried with magnesium sulfate
5. 5
   Concentrationconcentrated to an oil

Mode opératoire

A mixture of 2-chloro-3-trifluoromethylpyridine (3.62 g., 21 mmol), 3-trifluoromethylpyrazole (2.7 g., 20 mmol), and potassium carbonate (6.0 g, 43 mmol) were heated at 100° C. for 18 h. The cooled reaction mixture was added to ice/water (100 mL). The mixture was extracted twice with ether (100 mL) and the combined ether extracts were washed twice with water (100 mL). The organic layer was dried with magnesium sulfate and concentrated to an oil. Chromatography on silica gel with hexanes:ethyl acetate 8:1 to 4:1 as eluent gave the title compound (3.5 g) as an oil.

Source