Réaction #792145

Équation de réaction

(E)-1-(2-hydroxy-4-isobutoxyphenyl)-3-(pyridin-2-yl)prop-2-en-1-one

→

final compound

Rendement 84.7%

1-(2-hydroxy-4-isobutoxyphenyl)-3-(pyridine-2-yl)propan-1-one

Rendement 84.7%

Solvants

EtOAc

Conditions de réaction

Traitement

1. 1
   Autrewas conducted at atmospheric pressure room temperature until the starting material
2. 2
   FiltrationThe catalyst was filtered
3. 3
   Autrethe crude was purified by chromatography on silica gel (25% EtOAc/hexane)

Mode opératoire

In a 200 mL round-bottomed flask, (E)-1-(2-hydroxy-4-isobutoxyphenyl)-3-(pyridin-2-yl)prop-2-en-1-one (1.08 g, 3.63 mmol) and 80 mg of 10% Pd/C was mixed together in wet EtOAc (50 ml). Hydrogenation was conducted at atmospheric pressure room temperature until the starting material was gone. The catalyst was filtered and the crude was purified by chromatography on silica gel (25% EtOAc/hexane) to provide 0.92 g of final compound (82%) as off white solid.

Source