Réaction #79164

Équation de réaction

hydrogen chloride

N-(2-pyridyl)-o-phenylenediamine

(E)-2,4-difluorocinnamoyl chloride

(E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole

→

titled compound

(E)-2-(2.4-Difluorostyryl)-1-(2-pyridyl)-1H-benzimidazole hydrochloride

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   Autreobtained as
2. 2
   ConcentrationConcentration and recrystallization from ethyl acetate/ethanol

Mode opératoire

To a solution of (E)-2,4-difluorocinnamic acid (331 mg, 1.8 mmol) in benzene (10 ml) was added thionyl chloride (0.5 ml) and the mixture was heated to reflux for 60 min. Volatiles were removed by evaporation to give crude (E)-2,4-difluorocinnamoyl chloride. Free base of the titled compound was prepared from N-(2-pyridyl)-o-phenylenediamine (250 mg, 1.4 mmol) and (E)-2,4-difluorocinnamoyl chloride obtained as above according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A). The free base was dissolved with a 10% methanol solution of hydrogen chloride (5 ml). Concentration and recrystallization from ethyl acetate/ethanol yielded the titled compound. MW: 369.80; mp: 194.8-196.8° C.; 1H-NMR (DMSO) δ: 8.84-8.79 (1H, m), 8.30-8.08 (2H, m), 7.96-7.82 (3H, m), 7.78-7.69 (1H, m), 7.61-7.13 (6H, m).

Source