Réaction #79155

Équation de réaction

2-styryl-1H-benzimidazole

2-Chloropyrimidine

(E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole

oxalic acid

→

titled compound

(E)-1-(2-Pyrimidyl)-2-styryl-1H-benzimidazole oxalate

Solvants

ethyl acetate

Conditions de réaction

Traitement

1. 1
   ConcentrationConcentration and recrystallization from ethyl acetate-hexane

Mode opératoire

Free base of the titled compound was prepared from 2-styryl-1H-benzimidazole and 2-Chloropyrimidine according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method B). The free base and oxalic acid were dissolved into ethyl acetate. Concentration and recrystallization from ethyl acetate-hexane yielded the titled compound. MW: 388.39; mp: 167.0-168.0° C.; 1H-NMR (DMSO-d6) δ: 9.09 (2H, dd, J=5.1, 0.7), 8.13-8.07 (1H, m), 7.91 (2H, s), 7.76-7.70 (2H, m), 7.76 (1H, d, J=7.3 Hz), 7.63 (1H, td, J=4.8, 0.7 Hz), 7.41 (1H, d, J=7.7 Hz), 7.46-7.30 (4H, m).

Source