Réaction #790926

Équation de réaction

potassium hydroxide

ethylene glycol

3,4-methylenedioxynitrobenzene

→

2-hydroxy-4-nitrophenoxyethanol

Conditions de réaction

Traitement

1. 1
   Autrebeing kept in the region of 100° C
2. 2
   TempératureAfter heating for two hours
3. 3
   AutreThe expected product crystallizes in the form of the potassium phenate
4. 4
   FiltrationThe phenate is filtered off
5. 5
   workup.DISSOLUTIONredissolved in 250 ml of water
6. 6
   AutreThe 2-hydroxy-4-nitrophenoxyethanol precipitates
7. 7
   FiltrationAfter filtration
8. 8
   Lavagewashing with water
9. 9
   Autredrying in vacuo

Mode opératoire

0.2 mol (11.2 g) of potassium hydroxide is dissolved in 167 ml of ethylene glycol in a boiling water bath. 0.1 mol (16.7 g) of 3,4-methylenedioxynitrobenzene is added, with stirring, the temperature being kept in the region of 100° C. After heating for two hours, the reaction medium is cooled to -5° C. The expected product crystallizes in the form of the potassium phenate. The phenate is filtered off and then redissolved in 250 ml of water, and the solution is acidified to pH=6 with concentrated hydrochloric acid. The 2-hydroxy-4-nitrophenoxyethanol precipitates. After filtration, washing with water and drying in vacuo, the expected product melts at 158° C.

Source