Réaction #78927

Équation de réaction

compound 2

Methanesulfonic acid 1-[1-(4-chloro-phenyl)-cyclobutanecarbonyl]-piperidin-3-ylmethyl ester

1-(2-chlorophenyl)piperazine

cesium carbonate

→

7

Rendement 42.0%

[1-(4-Chloro-phenyl)-cyclobutyl]-{3-[4-(2-chloro-phenyl)-piperazin-1-ylmethyl]-piperidin-1-yl}-methanone

Rendement 42.0%

Conditions de réaction

Traitement

1. 1
   AutreCompound 7 was prepared

Mode opératoire

Compound 7 was prepared using the method of described in Example 3, starting with compound 2 (1.0 g, 2.60 mmol), 1-(2-chlorophenyl)piperazine (0.56 g, 2.86 mmol), and cesium carbonate (1.27 g, 3.90 mmol) to give 7 (0.53 g, 42%); C27H33Cl2N3O, LRMS (m/z)=487 (MH+).

Source