Réaction #7869

Équation de réaction

5-Chloro-2-(3-methoxy-4-pyridin-2-ylphenyl)-1,3-benzoxazole

HCl

→

5-chloro-2-(3-methoxy-4-pyridin-2-yl phenyl)-1,3-benzoxazole hydrochloride

Solvants

dichloromethane

diethyl ether

Conditions de réaction

Traitement

1. 1
   Autrereaction mixture
2. 2
   AutreConcentration of reaction mixture in vacuo

Mode opératoire

5-Chloro-2-(3-methoxy-4-pyridin-2-ylphenyl)-1,3-benzoxazole (26 mg) was stirred in dichloromethane. 1.0M HCl in diethyl ether (0.95 mL) was added and allowed reaction mixture to stir for 30 minutes. Concentration of reaction mixture in vacuo gave the desired compound, 5-chloro-2-(3-methoxy-4-pyridin-2-yl phenyl)-1,3-benzoxazole hydrochloride, as a pink solid. 1H NMR (CD3OD, 300 MHz) δ 8.88–7.46 (m, 10H), 4.11 (s, 3H). MS (ESI) 337 (M+H)+.

Source