Réaction #78196

Équation de réaction

3-hydroxybenzoic acid

iodine monochloride

→

title compound

3-Hydroxy-4-iodobenzoic acid

Solvants

acetic acid

Conditions de réaction

Traitement

1. 1
   Autrethe solvent was evaporated under reduced pressure
2. 2
   LavageThe residue was washed with 500 ml of 1% aqueous sodium thiosulfate solution twice
3. 3
   Séchagewith 500 ml of water twice and then dried to solid at 80° C. under reduced pressure

Mode opératoire

30.0 g (217 mmol) of 3-hydroxybenzoic acid was dissolved in 200 ml of acetic acid. 53.0 g (326 mmol) of iodine monochloride was added to the obtained solution at room temperature. They were stirred at 45° C. for 15 hours and then the solvent was evaporated under reduced pressure. The residue was washed with 500 ml of 1% aqueous sodium thiosulfate solution twice and with 500 ml of water twice and then dried to solid at 80° C. under reduced pressure to obtain the title compound.

Source