Réaction #78055

Équation de réaction

1-acetylpiperazine

4-fluorophenyl isocyanate

→

1-acetyl-4-(4-fluorophenylcarbamoyl)piperazine

Rendement 112.6%

Solvants

tetrahydrofuran

Conditions de réaction

Traitement

1. 1
   Autrethe solvent was removed by evaporation under reduced pressure
2. 2
   Autrethe residue was triturated with diisopropyl ether

Mode opératoire

To a stirred solution of 1-acetylpiperazine (0.648 g) in tetrahydrofuran (10 ml) was added 4-fluorophenyl isocyanate (0.574 g) at ambient temperature. After stirring at ambient temperature for 1 hour, the solvent was removed by evaporation under reduced pressure, and the residue was triturated with diisopropyl ether to give 1-acetyl-4-(4-fluorophenylcarbamoyl)piperazine (1.25 g).

Source