Réaction #78050

Équation de réaction

sulfuryl chloride

1-acetylpiperazine

triethylamine

→

1-acetylpiperazine-4-sulfonyl chloride

Solvants

chloroform

chloroform

Conditions de réaction

Traitement

1. 1
   Températureunder cooling on an ice-water bath
2. 2
   Filtrationa precipitate was collected by filtration
3. 3
   SéchageAfter drying over sodium hydroxide

Mode opératoire

A solution of sulfuryl chloride (3.55 ml) in chloroform (45 ml) was added a solution of 1-acetylpiperazine (5.66 mg) and triethylamine (6.16 ml) in chloroform (15 ml) dropwise under cooling on an ice-water bath. After stirring for 6 hours, a precipitate was collected by filtration. After drying over sodium hydroxide, 1-acetylpiperazine-4-sulfonyl chloride (2.43 g) was obtained.

Source