Réaction #77943

Équation de réaction

2-(4,5-dihydroisoxazol-3-yl)-3-methylaniline

dimethyl disulfide

n-butyl nitrite

→

3-(2-methyl-6-methylthiophenyl)-4,5-dihydroisoxazole

Conditions de réaction

Traitement

1. 1
   FiltrationFor work-up, the hot mixture is filtered through activated carbon
2. 2
   Lavagewashed with dilute hydrochloric acid and water
3. 3
   Concentrationconcentrated under reduced pressure
4. 4
   AutreThe product can be purified further by trituration with methyl tert-butyl ether

Mode opératoire

40 g (0.22 mol) of 2-(4,5-dihydroisoxazol-3-yl)-3-methylaniline and 1.5 g of copper powder are initially charged in 300 ml of dimethyl disulfide, and 26.1 g of n-butyl nitrite (0.23 mol) are added dropwise at 55-66° C. The mixture is then stirred at 60° C. for 1.5 hours. For work-up, the hot mixture is filtered through activated carbon and then washed with dilute hydrochloric acid and water and then concentrated under reduced pressure. This gives 44.5 g (88%) of a dark oil which solidifies after a while (content according to HPLC (95%). The product can be purified further by trituration with methyl tert-butyl ether.

Source