Réaction #77480

Équation de réaction

(−)-7-(2-chloro-5-fluorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline

hydrochloric acid

→

(−)-7-(2-chloro-5-fluorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride

Rendement 196.0%

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   Concentrationconcentrated
2. 2
   AutreThe resultant crystal was recrystallized from a solvent mixture of ethanol and water

Mode opératoire

A solution of (−)-7-(2-chloro-5-fluorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline (1.2 g) in ethanol (20 ml) was combined with concentrated hydrochloric acid (0.76 ml) and concentrated. The resultant crystal was recrystallized from a solvent mixture of ethanol and water to obtain (−)-7-(2-chloro-5-fluorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride (Compound J) (1.3 g, 99.4% ee). (This compound was proven to have an absolute configuration of an S form based in an X-ray crystal structure analysis.)

Source