Réaction #77471

Équation de réaction

sodium methoxide

(±)-7-(5-Fluoro-2-methylphenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride

→

(±)-7-(5-fluoro-2-methylphenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline

Rendement 83.8%

Solvants

methanol

methanol

Conditions de réaction

Traitement

1. 1
   ConcentrationThe mixture was concentrated under reduced pressure
2. 2
   Lavagethe residue was washed with water
3. 3
   Autredried

Mode opératoire

(±)-7-(5-Fluoro-2-methylphenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride (43.8 g) was suspended in methanol (300 ml), and treated dropwise with a 28% solution of sodium methoxide in methanol (53.1 g). The mixture was concentrated under reduced pressure, and the residue was washed with water and dried to obtain (±)-7-(5-fluoro-2-methylphenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline (33.0 g).

Source