Réaction #77254

Équation de réaction

4-amino-5-fluoro-2-(3-methylpicolinoyl)phenyl thiocyanate

ammonium hydroxide

→

title compound

Rendement 66.6%

5-Amino-6-fluoro-3-(3-methyl-2-pyridyl)-1,2-benzisothiazole

Rendement 66.6%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   AutreThe methanol is removed in vacuo
2. 2
   Filtrationthe resultant mixture is filtered

Mode opératoire

A mixture of 4-amino-5-fluoro-2-(3-methylpicolinoyl)phenyl thiocyanate(3.06 g, 0.0112 mole), concentrated ammonium hydroxide (300 ml) and methanol (300 ml) is stirred overnight at room temperature. The methanol is removed in vacuo and the resultant mixture is filtered to afford the title compound as a green solid (1.93 g, 66.6%) which is identified by NMR spectral analysis.

Source