Réaction #77086

ord-fae45423f30a43c2a2bd5a52120ef75c

Équation de réaction

COc1cc2c(cc1O)C(Cc1ccc(OC)c(OC)c1)N(CC(=O)NC1CCc3ccccc31)CC2
2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide
BrCC1CC1
cyclopropyl-methyl bromide
→
COc1ccc(CC2c3cc(OCC4CC4)c(OC)cc3CCN2CC(=O)NC2CCc3ccccc32)cc1OC
2-[1-(3,4-dimethoxy-benzyl)-7-(cyclopropyl-methoxy)-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide

Réactifs

COc1cc2c(cc1O)C(Cc1ccc(OC)c(OC)c1)N(CC(=O)NC1CCc3ccccc31)CC2
2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide
BrCC1CC1
cyclopropyl-methyl bromide

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

prepared by reaction of 2-[1-(3,4-dimethoxy-benzyl)-7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(indan-1-yl)-acetamide with cyclopropyl-methyl bromide

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US06703392B2uspto-grants-2004_03