Réaction #76562

Équation de réaction

ethyl 7-fluoro-4-hydroxy-3-quinolinecarboxylate

→

7-fluoro-4-hydroxy-3-quinolinecarboxylic acid

Rendement 92.2%

Solvants

sodium hydroxide

Conditions de réaction

Traitement

1. 1
   Températurewas heated
2. 2
   Températureat reflux for 3 hours during which time a solution
3. 3
   Autrewas obtained
4. 4
   Filtrationit was filtered
5. 5
   Filtrationthrough filter paper under vacuum
6. 6
   AutreThe resulting precipitate was collected
7. 7
   Lavagewashed with water
8. 8
   Autredried

Mode opératoire

A suspension of ethyl 7-fluoro-4-hydroxy-3-quinolinecarboxylate (65 g, 0.28 mol) in 10% sodium hydroxide (250 mL) was heated at reflux for 3 hours during which time a solution was obtained. The reaction mixture was allowed to cool to ambient temperature and then it was filtered through filter paper under vacuum. The filtrate was acidified with concentrated hydrochloric acid. The resulting precipitate was collected, washed with water and then dried to provide 53.5 g of 7-fluoro-4-hydroxy-3-quinolinecarboxylic acid as a white solid.

Source