Réaction #765

Équation de réaction

N#Cc1cnn2c(NC3CC3)cc

CC(=O)N(C)c1ccc2cc[n

→

CC(=O)N(C)c1ccc2ccn(

Rendement 15.9%

Solvants

CC(=O)N(C)C

Conditions de réaction

Mode opératoire

In microwave tube, added 5-chloro-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile (84mg), N-(1H-indol-6-yl)-N-methylacetamide (67 mg), Pd2(dba)3 (16 mg), (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (20mg) cesium carbonate(129 mg) in anhydrous DMA (0.5mL). under microwave 150C for 30 min. the mixture was filtered. washed with MeOH. combinde organic solvent, dried to dryness. The residue solid was washed with MeOH to give about 22mg offwhite solid (product.

Source