Réaction #76426

Équation de réaction

Methyl(4-hydroxy-3-nitrophenyl)acetate

methyl(4-hydroxy-3-nitrophenyl)acetate

→

methyl(3-amino-4-hydroxyphenyl)acetate

Rendement 98.4%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   Autrehad been consumed
2. 2
   FiltrationThe reaction mixture was filtered
3. 3
   Autreto remove the catalyst
4. 4
   Lavagethe filtercake was washed with methanol
5. 5
   ConcentrationThe combined filtrate and washings were concentrated in vacuo

Mode opératoire

Methyl(4-hydroxy-3-nitrophenyl)acetate [from step 3] (48.9 g, 0.23 mole) and 5% palladium on carbon were suspended in methanol and the resulting mixture was hydrogenated until all the starting material had been consumed. The reaction mixture was filtered to remove the catalyst and the filtercake was washed with methanol. The combined filtrate and washings were concentrated in vacuo, affording methyl(3-amino-4-hydroxyphenyl)acetate as a solid (41.0 g).

Source