Réaction #76376

Équation de réaction

6-bromo-naphthalene-2-ol

benzyl bromide

→

2-Benzyloxy-6-bromo-naphthalene

Solvants

DMF

cesium carbonate

Conditions de réaction

Traitement

1. 1
   Autrequenched with water
2. 2
   Extractionextracted with ethyl acetate:hexane (1:1)
3. 3
   Lavagewashed with brine, over MgSO4
4. 4
   Concentrationconcentrated in vacuo

Mode opératoire

To the commercially available 6-bromo-naphthalene-2-ol (1) (1 equi.) and benzyl bromide (2) (1 equi.) in DMF (3mL/mmole), cesium carbonate (1.25 equi.) was added at room temperature. The reaction mixture was stirred at that temperature for 24 h, quenched with water, extracted with ethyl acetate:hexane (1:1), washed with brine, over MgSO4, and concentrated in vacuo.

Source