Réaction #7595

Équation de réaction

4-chloro-6,7-dimethoxycinnoline hydrochloride

2-fluoro-5-hydroxy-4-methylaniline

→

4-(2-fluoro-5-hydroxy-4-methylanilino)-6,7-dimethoxycinnoline

Solvants

2-pentanol

Conditions de réaction

Traitement

1. 1
   Autre(prepared
2. 2
   TempératureAfter cooling
3. 3
   Filtrationthe solid was filtered off
4. 4
   Lavagewashed with isopropanol and ether
5. 5
   Autredried under vacuum

Mode opératoire

A solution of 4-chloro-6,7-dimethoxycinnoline hydrochloride (261 mg, 1 mmol), (prepared as described for the starting material in Example 1), and 2-fluoro-5-hydroxy-4-methylaniline (170 mg, 1.2 mmol), (prepared as described for the starting material in Example 11), in 2-pentanol (5 ml) was heated at 120° C. for 3 hours. After cooling, the solid was filtered off, washed with isopropanol and ether and dried under vacuum to give 4-(2-fluoro-5-hydroxy-4-methylanilino)-6,7-dimethoxycinnoline as an hydrochloride salt (301 mg, 82%).

Source