Réaction #75704

Équation de réaction

HCl

2-Methylthioquinoline-4-carboxylic acid methyl ester

sodium hydroxide

→

title compound

Rendement 104.2%

2-Methylthioquinoline-4-carboxylic acid

Rendement 104.2%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   workup.DISSOLUTIONhad dissolved
2. 2
   AutreThe precipitated solid was separated by filtration
3. 3
   Autredried

Mode opératoire

2-Methylthioquinoline-4-carboxylic acid methyl ester (0.40 g) in methanol:2N sodium hydroxide (2:1, 45 ml) was heated at 60° C. until all solid had dissolved. Volume of solvent was reduced to (15 ml) at reduced pressure and acidified with 2N HCl (16 ml). The precipitated solid was separated by filtration and dried to give the title compound (0.39 g). 1H NMR δ: 2.68 (3H, s), 7.56 (1H, m), 7.75-7.80 (2H, m), 7.96 (1H, d, J=8.2 Hz), 8.55 (1H, d), 13.91 (1H, brs).

Source