Réaction #75679

ord-b3314ddbf4d24b39acf27f68fdb1c33c

Équation de réaction

Nc1cc(Cl)cc(Cl)c1
3,5-dichloroaniline
CCC(=O)C(=O)[O-]
ethylglyoxalate
C/C=C\c1cc(OC)c(OC)cc1OC
β-asaron
O=C(O)C(F)(F)F
trifluoroacetic acid
→
CCOC(=O)C1Nc2cc(Cl)cc(Cl)c2C(c2cc(OC)c(OC)cc2OC)C1C
Compound 47
CCOC(=O)C1Nc2cc(Cl)cc(Cl)c2C(c2cc(OC)c(OC)cc2OC)C1C
5,7-dichloro-3-methyl-4-(2,4,5-trimethoxyphenyl)-1 ,2,3,4-tetrahydroquinoline-2-carboxylic Acid Ethyl Ester

Réactifs

Nc1cc(Cl)cc(Cl)c1
3,5-dichloroaniline
CCC(=O)C(=O)[O-]
ethylglyoxalate
C/C=C\c1cc(OC)c(OC)cc1OC
β-asaron
O=C(O)C(F)(F)F
trifluoroacetic acid

Réactifs

Aucun

Solvants

CC#N
acetonitrile

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

Compound 47 was prepared by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol β-asaron and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US06699877B2uspto-grants-2004_03