Réaction #75672

Équation de réaction

sodium hydroxide

3,5-dichloroaniline

ethylglyoxalate

4-bromostyrene

trifluoroacetic acid

→

Compound 40

4-(4-bromophenyl)-5,7-dichloro-1 ,2,3,4-tetrahydroquinoline-2-carboxylic Acid

Solvants

ethanol

acetonitrile

Conditions de réaction

Mode opératoire

Compound 40 was prepared by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol 4-bromostyrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile. Subsequent saponification was carried out using 1.0 ml of sodium hydroxide solution (6N water) in 20.0 ml of ethanol.

Source