Réaction #75639

Équation de réaction

3,5-dichloroaniline

ethylglyoxalate

cyclopentadiene

trifluoroacetic acid

→

Compound 1

Rendement 89.0%

7,9-dichloro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic Acid Ethyl Ester

Rendement 89.0%

Solvants

acetonitrile

Conditions de réaction

Mode opératoire

Compound 1 was prepared in a yield of 89% by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol cyclopentadiene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile.

Source