Réaction #75621

Équation de réaction

tert-butyl 3-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate

hydrochloric acid ethyl acetate

ethyl acetate

→

3-oxo-2-oxa-8-azaspiro[4.5]decane hydrochloride

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   Filtrationthe resulting crystals were collected by filtration

Mode opératoire

1.16 g of tert-butyl 3-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate was dissolved in 2.3 ml methanol, 4.6 ml of 4 N hydrochloric acid/ethyl acetate was added thereto, and the mixture was stirred at room temperature for 1 hr. 5 ml ethyl acetate was added thereto, and the resulting crystals were collected by filtration to give 700 mg of 3-oxo-2-oxa-8-azaspiro[4.5]decane hydrochloride.

Source