Réaction #7542

Équation de réaction

1-{2-[2-(1-benzothiophen-5-yl)ethoxy]ethyl}-3-pyrrolidinamine

oxalic acid

→

1-{2-[2-(1-benzothiophen-5-yl)ethoxy]ethyl}-3-pyrrolidinamine dioxalate

Rendement 89.6%

Solvants

ethyl acetate

ethyl acetate

Conditions de réaction

Traitement

1. 1
   workup.WAITat 5° C. for 1 hour
2. 2
   AutreThe crystals precipitated
3. 3
   Filtrationwere collected by filtration
4. 4
   Lavagewashed with ethyl acetate
5. 5
   Autredried

Mode opératoire

In 3.0 mL of ethyl acetate was dissolved 0.71 g of 1-{2-[2-(1-benzothiophen-5-yl)ethoxy]ethyl}-3-pyrrolidinamine, and to the solution was added a solution of 0.44 g of oxalic acid in 4.0 mL of ethyl acetate. The resulting mixture was stirred at room temperature for 1 hour and then at 5° C. for 1 hour. The crystals precipitated were collected by filtration, washed with ethyl acetate and then dried to obtain 1.03 g of 1-{2-[2-(1-benzothiophen-5-yl)ethoxy]ethyl}-3-pyrrolidinamine dioxalate as colorless crystals.

Source