Réaction #7527

Équation de réaction

2-chloro-4-methoxybenzyl alcohol

triethylamine

methanesulfonyl chloride

→

title compound

Rendement 61.0%

2-chloro-4-methoxybenzyl chloride

Rendement 61.0%

Solvants

dichloromethane

Conditions de réaction

Traitement

1. 1
   AutreThe solvent was evaporated under reduced pressure
2. 2
   workup.DISSOLUTIONthe obtained residue was dissolved in ethyl acetate
3. 3
   LavageThe organic layer was washed with saturated brine
4. 4
   Séchagedried over anhydrous sodium sulfate
5. 5
   AutreThe solvent was evaporated under reduced pressure

Mode opératoire

To a solution of 2-chloro-4-methoxybenzyl alcohol (1.5 g, 8.7 mmol) in dichloromethane (10 mL) were added under ice-cooling triethylamine (2.4 mL, 17.4 mmol) and methanesulfonyl chloride (0.74 mL, 9.5 mmol) and the mixture was stirred at room temperature for 2 h. The solvent was evaporated under reduced pressure and the obtained residue was dissolved in ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give an almost pure title compound (1.01 g, 61%).

Source