Réaction #7511

Équation de réaction

water

ethyl 4-hydroxy-2-(2,3-dihydro-1H-indol-1-yl)-5-pyrimidinecarboxylate

potassium carbonate

4-fluorobenzylbromide

→

title compound

Rendement 79.2%

ethyl 2-(2,3-dihydro-1H-indol-1-yl)-4-[(4-fluorobenzyl)oxy]-5-pyrimidinecarboxylate

Rendement 79.2%

Solvants

N,N-dimethylformamide

Conditions de réaction

Traitement

1. 1
   Températureto cool to room temperature
2. 2
   FiltrationThe precipitated crystals were collected by filtration
3. 3
   Lavagewashed several times with cold water and cold ether
4. 4
   Autredried

Mode opératoire

To a solution of ethyl 4-hydroxy-2-(2,3-dihydro-1H-indol-1-yl)-5-pyrimidinecarboxylate (7.1 g, 27.6 mmol) in N,N-dimethylformamide (100 ml) were added potassium carbonate (7.8 g, 60 mmol) and 4-fluorobenzylbromide (3.74 ml, 30 mmol) and the mixture was stirred at 80° C. for 18 h. The reaction mixture was allowed to cool to room temperature and water was added. The precipitated crystals were collected by filtration, washed several times with cold water and cold ether and dried to give the title compound (8.6 g, 79%).

Source