Réaction #74997

Équation de réaction

Acetophenone

1-isopropyl-2-methyl-5-trifluoromethyl-7-aminobenzimidazole

→

desired product

7-(alpha-methylbenzylidenamino)-1-isopropyl-2-methyl-5-trifluoromethylbenzimidazole

Solvants

xylene

Conditions de réaction

Traitement

1. 1
   SéchageAfter drying over sodium sulfate
2. 2
   Autrethe solvent was removed
3. 3
   Autrethe crude residue was recrystallized from benzene-cyclohexane (1:1)
4. 4
   Autreto give 3.38 g

Mode opératoire

Acetophenone (2.8 g.) was reacted with 1-isopropyl-2-methyl-5-trifluoromethyl-7-aminobenzimidazole (4.0 g.) in 50 ml. of xylene for 21 hours according to the procedure of Example 1. After drying over sodium sulfate, the solvent was removed and the crude residue was recrystallized from benzene-cyclohexane (1:1) to give 3.38 g. of the desired product, m.p. 164°-166° C.

Source