Réaction #7495

Équation de réaction

ethyl 2-bromobutanoate

potassium t-butoxide

ethyl acetate

5-phenyl-2-piperidinone

→

ester

Rendement 70.4%

Ethyl 2-(2-oxo-5-phenyl-1-piperidinyl)butanoate

Rendement 70.4%

Solvants

toluene

Conditions de réaction

Traitement

1. 1
   Températurewith reflux condenser, magnetic stirrer
2. 2
   Lavagethe solution was washed twice with brine
3. 3
   Séchagethe organic phase dried over magnesium sulfate
4. 4
   Filtrationfiltered
5. 5
   Concentrationconcentrated to dryness
6. 6
   AutreThe residue was purified by PrepLC (1 kg SiO2, CH2Cl2/EtOH, 97.5/2.5)

Mode opératoire

In a 1 l three necked flask fitted with reflux condenser, magnetic stirrer and dropping funnel under inert atmosphere, 9.8 g (87 mmoles) of potassium t-butoxide were suspended in 600 ml of dry toluene. 11.8 g (67 mmoles) of 5-phenyl-2-piperidinone 25 were added, and the mixture stirred for 30 min. 17 g (87 mmoles) of ethyl 2-bromobutanoate were added and the temperature raised to 70° C. for 5 hours. 600 ml of ethyl acetate were added, the solution was washed twice with brine, the organic phase dried over magnesium sulfate, filtered and concentrated to dryness. The residue was purified by PrepLC (1 kg SiO2, CH2Cl2/EtOH, 97.5/2.5) to give 3.7 g of pure ester 26 as a mixture of diastereomers, 70.4% yield.

Source