Réaction #74902

Équation de réaction

potassium carbonate

3,4-methylenedioxyphenol

α-bromoacetophenone

sodium carbonate

→

α-(3,4-methylenedioxyphenoxy)acetophenone

Solvants

benzene

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONA mixture of 25 g
2. 2
   Températurereflux temperature
3. 3
   Températuremaintained
4. 4
   Températureat reflux for 16 hours
5. 5
   workup.ADDITIONTo the mixture is added 50 g
6. 6
   Autrewhile collecting water in a Barrett water trap
7. 7
   workup.ADDITIONThe mixture is then diluted with a mixture of water and benzene
8. 8
   LavageThe benzene layer is washed with water
9. 9
   AutreIt is collected
10. 10
    Lavagerinsed with benzene
11. 11
    Autredried
12. 12
    Autreto provide a white powder which
13. 13
    Autreis recrystallized from ethanol

Mode opératoire

A mixture of 25 g. (0.181 mole) of 3,4-methylenedioxyphenol, 36 g. (0.181 mole) of α-bromoacetophenone and 41.2 g. (0.40 mole) of sodium carbonate in 350 ml. of benzene is heated to its reflux temperature and maintained at reflux for 16 hours. To the mixture is added 50 g. of potassium carbonate, and the mixture is refluxed for an additional 7 days while collecting water in a Barrett water trap. The mixture is then diluted with a mixture of water and benzene. The benzene layer is washed with water, then cold 5 percent sodium hydroxide solution. A precipitate forms in the benzene layer. It is collected, rinsed with benzene and dried to provide a white powder which is recrystallized from ethanol to provide α-(3,4-methylenedioxyphenoxy)acetophenone, m.p. 123°-126° C.

Source